Our lab has three areas of research:
Genetics of psychotic disorders.
What is the phenotypic profile of genetic risk for psychotic disorders? We are interested in how genetic risk manifests in symptom profiles, both cross-sectionally and longitudinally, as well as outcomes like recovery, remission, and treatment resistance. Our collaborators and us also study how different ways of measuring psychosis, as diagnoses or symptom dimensions, affect gene discovery.
Course of psychosis.
We work closely with Drs. Evelyn Bromet and Roman Kotov on the Suffolk County Mental Health Project, currently the longest-running study of first-episode psychosis in the world. We collaborate with researchers leading similar efforts across the globe to understand how symptoms, cognition, and functioning change over the course of illness in psychotic disorders.
We lead the HiTOP-DAT field trials, a collaborative effort to implement dimensional, transdiagnostic intake and follow-up assessments in psychiatric and psychological treatment facilities. The HiTOP-DAT is currently in use at 9 clinics across the world.
Jonas, K. (2021). Global Information for Multidimensional Tests. Applied Psychological Measurement.
Jonas, K., Abi-Dargham, A., & Kotov, R. (2021). Two Hypotheses on the High Incidence of Dementia in Psychotic Disorders. JAMA psychiatry.
Waszczuk, M. A., Eaton, N. R., Krueger, R. F., Shackman, A. J., Waldman, I. D., Zald, D. H., ... & Kotov, R. (2020). Redefining phenotypes to advance psychiatric genetics: Implications from hierarchical taxonomy of psychopathology. Journal of abnormal psychology, 129(2), 143.
Kotov, R., Jonas, K. G., Carpenter, W. T., Dretsch, M. N., Eaton, N. R., Forbes, M. K., ... & HiTOP Utility Workgroup. (2020). Validity and utility of hierarchical taxonomy of psychopathology (HiTOP): I. Psychosis superspectrum. World Psychiatry, 19(2), 151-172.
Jonas, K. G., Fochtmann, L. J., Perlman, G., Tian, Y., Kane, J. M., Bromet, E. J., & Kotov, R. (2020). Lead-time bias confounds association between duration of untreated psychosis and illness course in schizophrenia. American Journal of Psychiatry, 177(4), 327-334.
Jonas, K. G., Lencz, T., Li, K., Malhotra, A. K., Perlman, G., Fochtmann, L. J., ... & Kotov, R. (2019). Schizophrenia polygenic risk score and 20-year course of illness in psychotic disorders. Translational psychiatry, 9(1), 1-8.
Jonas, K. G., & Markon, K. E. (2019). Modeling response style using vignettes and person-specific item response theory. Applied psychological measurement, 43(1), 3-17.
Jonas, K., Clouston, S., Li, K., Fochtmann, L. J., Lencz, T., Malhotra, A. K., ... & Kotov, R. (2019). Apolipoprotein E-ε4 allele predicts escalation of psychotic symptoms in late adulthood. Schizophrenia research, 206, 82-88.
Jonas, K., & Kochanska, G. (2018). An imbalance of approach and effortful control predicts externalizing problems: Support for extending the dual-systems model into early childhood. Journal of abnormal child psychology, 46(8), 1573-1583.
Jonas, K. G., & Markon, K. E. (2016). A descriptivist approach to trait conceptualization and inference. Psychological Review, 123(1), 90.
Jonas, K. G., & Markon, K. E. (2014). A meta-analytic evaluation of the endophenotype hypothesis: Effects of measurement paradigm in the psychiatric genetics of impulsivity. Journal of Abnormal Psychology, 123(3), 660.
Jonas, K. G., & Markon, K. E. (2013). A model of psychosis and its relationship with impairment. Social psychiatry and psychiatric epidemiology, 48(9), 1367-1375.
We are currently reconnecting with members of the Genomic Psychiatry Cohort to see how things have changed over the years.
We are interested in seeing how people do over time: some people's symptoms change, and other people's stay the same. We are trying to understand if a person’s genes influence how a person fares over the long run. The interview lasts about an hour and a half, where we ask questions about people's day-to-day life, and any symptoms they might have experienced since the last interview.
If you are member of the cohort and wish to participate, please fill out the form in our Contact Us section.
More information about the Genomic Psychiatry Cohort is available in the following publication:
Pato, M. T., Sobell, J. L., Medeiros, H., Abbott, C., Sklar, B. M., Buckley, P. F., ... & Pato, C. N. (2013). The genomic psychiatry cohort: partners in discovery. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162(4), 306-312.
A Collaborative & Diverse Group
Katherine Jonas PhD LP is the lab’s principal investigator. Dr. Jonas received her bachelor’s degree cum laude from Harvard University in 2008. She completed her doctorate in clinical psychology at the University of Iowa, graduating in 2017 after a clinical internship at the Minneapolis VA. She completed her postdoctoral training in the Department of Psychiatry & Behavioral Health at Stony Brook, and has been licensed in New York State since 2019. She joined the faculty at Stony Brook as Assistant Professor in 2021.
Dr. Jonas is interested in the course of psychotic disorders, and in particular, how genetic risk factors impact a person’s symptoms, course of illness, and response to treatment. She is also interested in the design of genetic association studies, and approaches that can improve the power and precision of genetic research. This work is funded by the National Institutes of Mental Health (K08 MH122673 and R21 MH123908).
Wenxuan (Wendy) Lian
Wendy is a PhD student at the Department of Applied Mathematics and Statistics. She graduated from Stony Brook with a M.S in both Materials Science and Applied Mathematics. Wendy is currently working as a data analyst in the lab. Her specialties include multivariate time series, factor modeling and survival analysis.
Sara Tramazzo received her B.A. in Psychology from Stony Brook University in 2019. In addition to being a coordinator and interviewer for The Genomic Psychiatry Cohort under Dr. Jonas, Sara also is a research coordinator for The Suffolk County Mental Health Project, a longitudinal study following first episode psychosis under Dr. Kotov. She is interested in using the etiology of schizophrenia spectrum disorders to improve treatment outcomes and hopes to pursue a PhD in clinical psychology.
David received his B.S. degree in Psychology from the University of Massachusetts Amherst in 2019. David has since worked at Stony Brook University in a variety of roles within the Psychology field. Currently he is a research coordinator working within Jonas Labs. David hopes to pursue a PhD/PsyD in clinical psychology and work with adolescents in the future.
Jeremy Kunins is an undergraduate student pursuing his B.S. in Psychology at Stony Brook University. He currently works as an interviewer for the Genomic Psychiatry Cohort under Dr. Jonas, and plans to pursue a PhD in Neuropsychology. He’s interested in working alongside individuals with neurological disorders to aid in treatment and further the body of research.
Grimm has no credentials and no aspirations, making him an outstanding mascot.
We welcome inquiries from prospective research assistants, especially those interested in learning more about careers in research. We are currently taking on volunteer research assistants to help with the 10-year follow-up of the GPC cohort. If you are interested in being part of this project, please complete the “Contact Us” form below.
We currently have have an opening for a postdoctoral research fellow. The postdoctoral fellow would be primarily involved in our psychiatric genetic research. Please see the complete job description here.